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Clinical Perspectives: Optimal Use of PK/PD in Antifungal Selection

Program Overview

Dr. Richard Drew and Dr. James Lewis discuss the importance of using pharmacokinetic and pharmacodynamic parameters when choosing an appropriate antifungal agent. Clinically relevant PK/PD differences among the antifungal classes are also reviewed.

Target Audience

This activity has been designed to meet the needs of physicians and all other healthcare professionals who care for and who may be involved in the diagnosis, management, and treatment of invasive fungal infections.

Learning Objectives

At the conclusion of this activity, participants should be better able to:

  • Discuss the role of pharmacokinetic/pharmacodynamic characteristics in the selection of antifungal agents for the treatment of invasive fungal infections

Faculty

Richard H. Drew, PharmD
Professor of Pharmacy
Campbell University School of Pharmacy
Duke University Medical Center
Durham, North Carolina

James S. Lewis, PharmD
Infectious Diseases Pharmacy Programs Manager

Clinical Assistant Professor
University Health System, Department of Pharmacy
University of Texas Health Science Center, San Antonio
San Antonio, Texas

Physician Accreditation

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of CME, Inc. and Vemco MedEd, LLC. The American Academy of CME is accredited by the ACCME to provide continuing medical education for physicians.

The American Academy of CME designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Release Date: Monday, September 24, 2007
Expiration Date: Tuesday, September 23, 2008
Estimated Time to Complete Activity: 0.5 hour

Disclosure Statement

According to the disclosure policy of the Academy, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of the Academy to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation. All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Disclosures

Richard H. Drew, PharmD has received research support from Cubist, NeuTec, and Schering-Plough. He serves as a consultant for Merck, Schering-Plough, and Theravance. Also, he is a speaker for Enzon, Ortho-McNeil, Sanofi-Aventis, and Schering-Plough Corporation.

James S. Lewis, PharmD serves as a consultant and and is a speaker for Astellas, Pfizer, and Schering-Plough.

Planning Committee Members: Karen Wetzel, American Academy of CME and Vesna Drenovac, RPh, MS, and Marco Cicero, PhD, Vemco MedEd have disclosed that they have no relevant financial relationships with any commercial interests.

Off-label Disclosure Statement

At the time of the release of this CME activity, the following non-FDA-approved off-label use of the following antifungal agent is discussed in this activity: liposomal formulation of amphotericin B at a dose of 10 mg/kg per day.

Fee

There is no fee to participate in this educational activity.

Method of Participation

To receive credit for your participation in this CME podcast activity, please complete the following steps:

  1. Review the CME information including the target audience, learning objective, and disclosures.
  2. Listen to and review the program carefully.
  3. Complete the CME Post-test, selecting the most appropriate response to each question.
  4. Complete the CME Evaluation Form and Credit Information.
  5. Fax the Evaluation Form and Credit Information to (609) 921-6428 or mail to: American Academy of CME, 186 Tamarack Circle, Skillman, NJ 08558. Documentation of credit will be mailed within 6-8 weeks following receipt of your materials.
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Hardware/Software Requirements

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    Jointly sponsored by the American Academy of CME, Inc. and Vemco MedEd, LLC

         Supported by an educational grant from Schering-Plough Corporation
 
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