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The Echinocandin “Eagle” Effect and Its Clinical Significance

Program Overview

Dr. Jack Sobel and Dr. James Lewis critically evaluate an important study by Chamilos and colleagues, titled "Paradoxical Effect of Echinocandins Across Candida species In Vitro: Evidence for Echinocandin-specific and Candida Species-related Differences" published in Antimicrobial Agents and Chemotherapy. In the course of their discussion, Drs. Sobel and Lewis debate the clinical significance of this paradoxical or "eagle" effect seen in vitro with echinocandins for Candida species.

Target Audience

This activity has been designed to meet the needs of physicians and all other healthcare professionals who care for and who may be involved in the diagnosis, management, and treatment of invasive fungal infections.

Learning Objectives

Discuss the clinical significance of the echinocandin “eagle” effect

Faculty

Jack D. Sobel, MD
Professor of Medicine
Wayne State University School of Medicine
Detroit, Michigan

James S. Lewis, PharmD
Infectious Diseases Pharmacy Programs Manager

Clinical Assistant Professor
University Health System, Department of Pharmacy
University of Texas Health Science Center, San Antonio
San Antonio, Texas

Physician Accreditation

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of CME, Inc. and Vemco MedEd, LLC. The American Academy of CME is accredited by the ACCME to provide continuing medical education for physicians.

The American Academy of CME designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Release Date: Friday, September 14, 2007
Expiration Date: Saturday, September 13, 2008
Estimated Time to Complete Activity: 0.5 hour

Disclosure Statement

According to the disclosure policy of the Academy, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of the Academy to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation. All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Disclosures

Jack D. Sobel, MD has received research support from Astellas, Merck, and Pfizer. Dr. Sobel was the principal investigator and the funds were paid to, Wayne State University, his institution. Additionally, Dr. Sobel serves as a scientific consultant for Pfizer.

James S. Lewis, PharmD serves as a consultant and and is a speaker for Astellas, Pfizer, and Schering-Plough.

Planning Committee Members: Karen Wetzel, American Academy of CME and Vesna Drenovac, RPh, MS, and David Christiansen, PhD, Vemco MedEd have disclosed that they have no relevant financial relationships with any commercial interests.

Off-label Disclosure Statement

Off-label and investigational use of drugs is not discussed in this activity.

Fee

There is no fee to participate in this educational activity.

Method of Participation

To receive credit for your participation in this CME podcast activity, please complete the following steps:

  1. Review the CME information including the target audience, learning objective, and disclosures.
  2. Listen to and review the program carefully.
  3. Complete the CME Post-test, selecting the most appropriate response to each question.
  4. Complete the CME Evaluation Form and Credit Information.
  5. Fax the Evaluation Form and Credit Information to (609) 921-6428 or mail to: American Academy of CME, 186 Tamarack Circle, Skillman, NJ 08558. Documentation of credit will be mailed within 6-8 weeks following receipt of your materials.
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    Jointly sponsored by the American Academy of CME, Inc. and Vemco MedEd, LLC

         Supported by an educational grant from Schering-Plough Corporation
 
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