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Rational Use of Antifungal Prophylaxis in High-Risk Patients

Program Overview

Dr. Richard Drew and Dr. John Perfect evaluate clinical study results recently published in an article in the New England Journal of Medicine titled, "Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia." During the course of their discussion, Dr. Drew and Dr. Perfect discuss the rational use of antifungal prophylaxis in high-risk patients and how patient management may evolve in the coming years due to improved diagnostic techniques.

Target Audience

This activity has been designed to meet the needs of physicians and all other healthcare professionals who care for and who may be involved in the diagnosis, management, and treatment of invasive fungal infections.

Learning Objectives

At the conclusion of this activity, participants should be better able to:

  • Recognize which high-risk patient populations may benefit with using a mold-active agent for antifungal prophylaxis

Faculty

Richard H. Drew, PharmD
Professor of Pharmacy
Campbell University School of Pharmacy
Associate Professor of Medicine
Duke University School of Medicine
Durham, North Carolina

John R. Perfect, MD
Professor of Medicine

Duke University Medical Center
Durham, North Carolina

Physician Accreditation

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of CME, Inc. and Vemco MedEd, LLC. The American Academy of CME is accredited by the ACCME to provide continuing medical education for physicians.

The American Academy of CME designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Release Date: Tuesday, December 11, 2007
Expiration Date: Wednesday, December 10, 2008
Estimated Time to Complete Activity: 0.5 hour

Disclosure Statement

According to the disclosure policy of the Academy, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of the Academy to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation. All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

Disclosures

Richard H. Drew, PharmD has received research support from Cubist, NeuTec, and Schering-Plough. He serves as a consultant for Merck, Schering-Plough, and Theravance. Also, he is a speaker for Enzon, Ortho-McNeil, Sanofi-Aventis, and Schering-Plough Corporation.

John R. Perfect, MD has received research support from Astellas, Enzon, Merck, Pfizer, and Schering-Plough. Dr. Perfect was the principal investigator and the funds were paid to Duke, his institution. Additionally, Dr. Perfect serves as a scientific consultant for Astellas, Enzon, Merck, Pfizer, and Schering-Plough and he serves on the scientific advisory board for Astellas, Enzon, Merck, Pfizer, and Schering-Plough.

Planning Committee Members: Karen Wetzel, American Academy of CME and Vesna Drenovac, RPh, MS, and Marco Cicero, PhD, Vemco MedEd have disclosed that they have no relevant financial relationships with any commercial interests.

Off-label Disclosure Statement

At the time of the release of this CME activity, the following off-label uses of the following antifungal agents are discussed in this educational activity: itraconazole (for prophylaxis); voriconazole (for prophylaxis).

Fee

There is no fee to participate in this educational activity.

Method of Participation

To receive credit for your participation in this CME podcast activity, please complete the following steps:

  1. Review the CME information including the target audience, learning objective, and disclosures.
  2. Listen to and review the program carefully.
  3. Complete the CME Post-test, selecting the most appropriate response to each question.
  4. Complete the CME Evaluation Form and Credit Information.
  5. Fax the Evaluation Form and Credit Information to (609) 921-6428 or mail to: American Academy of CME, 186 Tamarack Circle, Skillman, NJ 08558. Documentation of credit will be mailed within 6-8 weeks following receipt of your materials.
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Hardware/Software Requirements

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    Jointly sponsored by the American Academy of CME, Inc. and Vemco MedEd, LLC

         Supported by an educational grant from Schering-Plough Corporation
 
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